Gene

ppp2r3b

ID

ZDB-GENE-070912-268

Name

protein phosphatase 2, regulatory subunit B'', beta

Symbol

ppp2r3b Nomenclature History

Previous Names

im:6895423
si:ch211-269e2.2 (1)

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have protein phosphatase regulator activity. Predicted to be involved in protein dephosphorylation. Predicted to localize to protein phosphatase type 2A complex. Orthologous to human PPP2R3B (protein phosphatase 2 regulatory subunit B''beta).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6895423 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Seda et al., 2023
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ppp2r3b Human Ortholog

No data available

Associated With ppp2r3b Via Experimental Models

Human Disease	Fish	Conditions	Citations
idiopathic scoliosis	ppp2r3b^u1001/u1001	standard conditions	Seda et al., 2023

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018247	EF-Hand 1, calcium-binding site
Domain	IPR002048	EF-hand domain
Domain	IPR041534	PP2A regulatory subunit B'', EF-hand domain
Domain	IPR048855	Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha/beta/delta, EF-hand
Homologous_superfamily	IPR011992	EF-hand domain pair

Domain Details Per Protein

Protein	Length	EF-Hand 1, calcium-binding site	EF-hand domain	EF-hand domain pair	PP2A regulatory subunit B'', EF-hand domain	Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha/beta/delta, EF-hand
UniProtKB:A0A8M2BFY8 InterPro	582
UniProtKB:A0A8M9QBH6 InterPro	509
UniProtKB:A0A8M9Q569 InterPro	513
UniProtKB:A0A8M9QKA7 InterPro	508
UniProtKB:B0S5T6 InterPro	583

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ppp2r3b-201 (1) Ensembl	Ensembl	2,392 nt	Select Tool
mRNA	ppp2r3b-202 (1) Ensembl	Ensembl	1,445 nt	Select Tool
mRNA	ppp2r3b-204 (1) Ensembl	Ensembl	1,910 nt	Select Tool ZFIN BLAST
ncRNA	ppp2r3b-003 (1) Ensembl	Ensembl	599 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations